Medicina herbal y COVID largo: Nuevas retos para la investigación

Brian Johan Bustos-Viviescas, Elizabeth Lizcano Rojas, Carlos Enrique García Yerena

Resumen


DOI: https://doi.org/10.53766/AcBio/2024.14.28.22

Introducción: La comprensión de la fisiopatología del COVID largo y su tratamiento por medio de la medicina tradicional (específicamente la medicina herbal), es un tema de interés creciente dada la prevalencia en actual del COVID largo en diferentes poblaciones y las complicaciones en el bienestar, calidad de vida y funcionalidad de los afectados por estas secuelas persistentes. Objetivo: Analizar la pertinencia de los estudios en medicina herbal para los procesos de tratamiento del COVID largo y consideraciones desde la salud pública. Desarrollo: Posterior a la revisión de literatura se estructuraron 3 apartados principales: 1) COVID largo una problemática emergente de la salud pública, 2) Avances en medicina herbal y COVID largo, 3) Consideraciones para el abordaje del COVID largo desde la medicina herbal, en el primero se analizaron aspectos como la prevalencia y complicaciones ocasionadas por el COVID largo en el marco de la salud pública, en el segundo se enfatizo las investigaciones realizadas hasta la fecha de medicina herbal y el abordaje de pacientes con COVID largo, mientras que para el último se describieron las limitaciones y oportunidades para la investigación y tratamiento de esta fisiopatología emergente desde la medicina herbal. Recomendaciones finales: Se evidencia la necesidad de reconocer la importancia de un seguimiento interdisciplinario con un enfoque holístico que incluya aspectos como la nutrición, fisioterapia y la intervención psicológica; con el fin de encontrar respuestas a los tratamientos más favorables para la población objeto de estudio desde la medicina herbal.

Recibido: 24/04/2024
Aceptado: 05/06/2024


Palabras clave


Medicina de Hierbas; Plantas Medicinales; Fitoterapia; Naturopatía; Síndrome Post Agudo de COVID-19

Texto completo:

PDF

Referencias


Gonzalez-Hernandez R. Fitofármacos: una alternativa de salud durante la COVID-19. Revista Cubana de Plantas Medicinales [Internet]. 2021 [citado 22 Sep 2023]; 25 (4) Disponible en: https://revplantasmedicinales.sld.cu/index.php/pla/article/view/1165

Vega-Jiménez J. La medicina tradicional herbolaria como base de la medicina científica. Revista Cubana de Plantas Medicinales [Internet]. 2020 [citado 22 Sep 2023]; 25 (2) Disponible en: https://revplantasmedicinales.sld.cu/index.php/pla/article/view/1032

Panyod S, Ho CT, Sheen LY. Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. J Tradit Complement Med. 2020;10(4):420-427. DOI: 10.1016/j.jtcme.2020.05.004

Huang J, Tao G, Liu J, Cai J, Huang Z, Chen JX. Current Prevention of COVID-19: Natural Products and Herbal Medicine. Front Pharmacol. 2020;11:588508. DOI: 10.3389/fphar.2020.588508

Setayesh M, Karimi M, Zargaran A, Abousaidi H, Shahesmaeili A, Amiri F, et al. Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): A randomized controlled trial. Integr Med Res. 2022;11(3):100869. DOI: 10.1016/j.imr.2022.100869

Feng Z, Yang J, Xu M, Lin R, Yang H, Lai L, et al. Dietary supplements and herbal medicine for COVID-19: A systematic review of randomized control trials. Clin Nutr ESPEN. 2021;44:50–60. DOI: 10.1016/j.clnesp.2021.05.018

Liu M, Gao Y, Yuan Y, Yang K, Shi S, Tian J, et al. Efficacy and safety of herbal medicine (Lianhuaqingwen) for treating COVID-19: A systematic review and meta-analysis. Integr Med Res. 2021;10(1):100644. DOI: 10.1016/j.imr.2020.100644

Fan AY, Gu S, Alemi SF; Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. J Integr Med. 2020;18(5):385-394. DOI: 10.1016/j.joim.2020.07.008

Ang L, Lee HW, Kim A, Lee JA, Zhang J, Lee MS. Herbal medicine for treatment of children diagnosed with COVID-19: A review of guidelines. Complement Ther Clin Pract. 2020;39:101174. DOI: 10.1016/j.ctcp.2020.101174

López-Hernández Y, Monárrez-Espino J, López DAG, Zheng J, Borrego JC, Torres-Calzada C, et al. The plasma metabolome of long COVID patients two years after infection. Sci Rep. 2023;13(1). DOI: 10.1038/s41598-023-39049-x

Takakura K, Suka M, Kajihara M, Koido S. Clinical features, therapeutic outcomes, and recovery period of long COVID. J Med Virol. 2023;95(1):e28316. DOI: 10.1002/jmv.28316

Chee YJ, Fan BE, Young BE, Dalan R, Lye DC. Clinical trials on the pharmacological treatment of long COVID: A systematic review. J Med Virol. 2023;95(1):e28289. DOI: 10.1002/jmv.28289

Altmann DM, Whettlock EM, Liu S, Arachchillage DJ, Boyton RJ. The immunology of long COVID [published online ahead of print, 2023 Jul 11] [published correction appears in Nat Rev Immunol. 2023 Sep 18;:]. Nat Rev Immunol. 2023;10.1038/s41577-023-00904-7. DOI: 10.1038/s41577-023-00904-7

Castanares-Zapatero D, Chalon P, Kohn L, Dauvrin M, Detollenaere J, Maertens de Noordhout C, et al. Pathophysiology and mechanism of long COVID: a comprehensive review. Ann Med. 2022;54(1):1473–87. DOI: 10.1080/07853890.2022.2076901

Roth A, Chan PS, Jonas W. Addressing the Long COVID Crisis: Integrative Health and Long COVID. Glob Adv Health Med. 2021;10:21649561211056597. 16. DOI: 10.1177/21649561211056597

Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re’em Y, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021;38(101019):101019. DOI: 10.1016/j.eclinm.2021.101019

Mangion K, Berry C. Multisystem involvement in COVID-19: what have we learnt?. Br J Hosp Med (Lond). 2022;83(8):1-5. DOI: 10.12968/hmed.2022.0290

Stafie CS, Solomon SM, Sufaru I-G, Manaila M, Stafie II, Melinte G, et al. Pathogenic connections in post-COVID conditions: What do we know in the large unknown? A narrative review. Viruses. 2022;14(8):1686. DOI: 10.3390/v14081686

Houeze EA, Wang Y, Zhou Q, Zhang H, Wang X. Comparison study of Beninese and Chinese herbal medicines in treating COVID-19. J Ethnopharmacol. 2023;308:116172. DOI: 10.1016/j.jep.2023.116172

Vega-Jiménez J, Medina-Nogueria D, González-Mejía K, Rabasco-Zamora M, Pérez-Recio M, Vega-Candelario R. Análisis bibliométrico de la producción científica de la Revista Cubana de Plantas Medicinales. Revista Cubana de Plantas Medicinales [Internet]. 2023 [citado 4 Sep 2023]; 27 (3) Disponible en: https://revplantasmedicinales.sld.cu/index.php/pla/article/view/1336

Rai M, Singh AV, Paudel N, Kanase A, Falletta E, Kerkar P, et al. Herbal concoction Unveiled: A computational analysis of phytochemicals’ pharmacokinetic and toxicological profiles using novel approach methodologies (NAMs). Curr Res Toxicol. 2023;5(100118):100118. DOI: 10.1016/j.crtox.2023.100118

Gasmi A, Shanaida M, Oleshchuk O, Semenova Y, Mujawdiya PK, Ivankiv Y, et al. Natural ingredients to improve immunity. Pharmaceuticals (Basel). 2023;16(4):528. DOI: 10.3390/ph16040528

Hernández-Parets M, Zayas-González M, Martínez-Fernández F, Brito-Ferrer Y, Medina-Corso B, González-Sánchez N. Alimentos funcionales y plantas medicinales versus COVID-19. Revista Cubana de Plantas Medicinales [Internet]. 2022 [citado 4 Sep 2023]; 27 (1) Disponible en: https://revplantasmedicinales.sld.cu/index.php/pla/article/view/1223

Catalano A, Iacopetta D, Ceramella J, Maio ACD, Basile G, Giuzio F, et al. Are nutraceuticals effective in COVID-19 and post-COVID prevention and treatment? Foods. 2022;11(18):2884. DOI: 10.3390/foods11182884

Ang L, Song E, Hu XY, Lee HW, Chen Y, Lee MS. Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis. Front Pharmacol. 2022;13:906764. DOI: 10.3389/fphar.2022.906764

Wu H-T, Ji C-H, Dai R-C, Hei P-J, Liang J, Wu X-Q, et al. Traditional Chinese medicine treatment for COVID-19: An overview of systematic reviews and meta-analyses. J Integr Med. 2022;20(5):416–26. DOI: 10.1016/j.joim.2022.06.006

Kim TH, Jeon SR, Kang JW, Kwon S. Complementary and Alternative Medicine for Long COVID: Scoping Review and Bibliometric Analysis. Evid Based Complement Alternat Med. 2022;2022:7303393. DOI: 10.1155/2022/7303393

Tong L, Ma Z, Zhou Y, Yang S, Yang Y, Luo J, et al. Combination of Chinese herbal medicine and conventional western medicine for coronavirus disease 2019: a systematic review and meta-analysis. Front Med (Lausanne). 2023;10. DOI: 10.3389/fmed.2023.1175827

Jegal KH, Yoon J, Kim S, Jang S, Jin Y-H, Lee J-H, et al. Herbal medicines for post-acute sequelae (fatigue or cognitive dysfunction) of SARS-CoV-2 infection: A phase 2 pilot clinical study protocol. Healthcare (Basel). 2022;10(10):1839. DOI: 10.3390/healthcare10101839

Komariah M, Amirah S, Maulana S, Abdurrahman MF, Ibrahim K, Platini H, et al. The efficacy of herbs as complementary and alternative therapy in recovery and clinical outcome among people with COVID-19: A systematic review, meta-analysis, and meta-regression. Ther Clin Risk Manag. 2023;19:611–27. DOI: 10.2147/tcrm.s405507

Chiang CY, Lin YJ, Weng WT, et al. Recuperative herbal formula Jing Si maintains vasculature permeability balance, regulates inflammation and assuages concomitants of "Long-Covid". Biomed Pharmacother. 2023;163:114752. DOI: 10.1016/j.biopha.2023.114752

Tokumasu K, Ueda K, Honda H, Sunada N, Sakurada Y, Matsuda Y, et al. Application of Kampo medicines for treatment of general fatigue due to long COVID. Medicina (Kaunas). 2022;58(6):730. DOI: 10.3390/medicina58060730

Karosanidze I, Kiladze U, Kirtadze N, Giorgadze M, Amashukeli N, Parulava N, et al. Efficacy of adaptogens in patients with long COVID-19: A randomized, quadruple-blind, placebo-controlled trial. Pharmaceuticals (Basel). 2022;15(3):345. DOI: 10.3390/ph15030345

Prajapati SK, Malaiya A, Mishra G, Jain D, Kesharwani P, Mody N, et al. An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations. J Ethnopharmacol. 2022;296(115420):115420. DOI: 10.1016/j.jep.2022.115420

Wang Z, Yang L. Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts. J Ethnopharmacol. 2021;270:113869. DOI: 10.1016/j.jep.2021.113869

Li Y, Qin Y, Chen N, Ge L, Wang Q, Aboudou T, et al. Use of traditional Chinese medicine for the treatment and prevention of COVID-19 and rehabilitation of COVID-19 patients: An evidence mapping study. Front Pharmacol. 2023;14. DOI: 10.3389/fphar.2023.1069879

Luo J, Zhang J, Tang HT, Wong HK, Lyu A, Cheung CH, et al. Prevalence and risk factors of long COVID 6–12 months after infection with the Omicron variant among nonhospitalized patients in Hong Kong. J Med Virol. 2023;95(6). DOI: 10.1002/jmv.28862

Li L, Xie H, Wang L, Zhang A, Mou X, Lin Y, et al. The efficacy and safety of combined chinese herbal medicine and western medicine therapy for COVID-19: a systematic review and meta-analysis. Chin Med. 2022;17(1). DOI1: 10.1186/s13020-022-00600-z

Bradbury J, Wilkinson S, Schloss J. Nutritional Support During Long COVID: A Systematic Scoping Review [published online ahead of print, 2023 Apr 26]. J Integr Complement Med. 2023;10.1089/jicm.2022.0821. DOI: 10.1089/jicm.2022.0821

Raveendran AV, Jayadevan R, Sashidharan S. Long COVID: An overview [published correction appears in Diabetes Metab Syndr. 2022 May;16(5):102504] [published correction appears in Diabetes Metab Syndr. 2022 Dec;16(12):102660]. Diabetes Metab Syndr. 2021;15(3):869-875. DOI: 10.1016/j.dsx.2021.04.007

Yang F, Zhang Q, Yuan Z, Teng S, Cui L, Xue F, et al. Signaling potential therapeutic herbal medicine prescription for treating COVID-19 by collaborative filtering. Front Pharmacol. 2021;12. DOI: 10.3389/fphar.2021.759479

Reese JT, Blau H, Casiraghi E, Bergquist T, Loomba JJ, Callahan TJ, et al. Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes. EBioMedicine. 2023;87(104413):104413. DOI: 10.1016/j.ebiom.2022.104413

Antony B, Blau H, Casiraghi E, Loomba JJ, Callahan TJ, Laraway BJ, et al. Predictive models of long COVID. EBioMedicine. 2023;96(104777):104777. DOI: 10.1016/j.ebiom.2023.104777

Morales-Pérez M, García-Mesa M, Acosta-de-la-Luz L, Vega-Jiménez J, Céspedes-Martínez I, Perdomo-Delgado J. Una alternativa natural para el tratamiento de la COVID-19. Revista Cubana de Plantas Medicinales [Internet]. 2020 [citado 22 Sep 2023]; 25 (1) Disponible en: https://revplantasmedicinales.sld.cu/index.php/pla/article/view/1024

DiPietro MA, Mondie C. Toxicity of herbal medications suggested as treatment for COVID-19: A narrative review. J Am Coll Emerg Physicians Open. 2021;2(2):e12411. DOI: 10.1002/emp2.12411

Deer RR, Rock MA, Vasilevsky N, Carmody L, Rando H, Anzalone AJ, et al. Characterizing long COVID: Deep phenotype of a complex condition. EBioMedicine. 2021;74(103722):103722. DOI: 10.1016/j.ebiom.2021.103722

Leaman R, Islamaj R, Allot A, Chen Q, Wilbur WJ, Lu Z. Comprehensively identifying Long Covid articles with human-in-the-loop machine learning. Patterns (N Y). 2023;4(1):100659. DOI: 10.1016/j.patter.2022.100659




DOI: https://www.doi.org/10.53766/AcBio/

Se encuentra actualmente indizada en:

tanaman herbal berkhasiat obat  

Creative Commons License
Todos los documentos publicados en esta revista se distribuyen bajo una
Licencia Creative Commons Atribución -No Comercial- Compartir Igual 4.0 Internacional.
Por lo que el envío, procesamiento y publicación de artículos en la revista es totalmente gratuito.